Biotechnological production

For some decades now, production capacities for biopharmaceutical products, mostly antibodies, have been limited. Production capacities are therefore being expanded worldwide. In addition, new, patient-based therapies, such as stem cell or car-T cell therapies, require new production capacities.

Whether microbial large-scale production of small molecules in bioreactors of 5 - 100 m3 or cell culture-based production in Singel Use Technology, our interdisciplinary team will support you in the planning of your production plant. In addition, we can draw on our know-how from successfully implemented projects.

Chemgineering assists your design projects with a well-trained team of specialists.

Wolfgang Minas

Global Head Biotech Design

Chemgineering assists your design projects with a well-trained team of specialists.

Successfully completed studies:

Scale up
Process evaluations
Feasibility studies on both technical and economic aspects
Technical Due diligence and site evaluations
Process simulations
Containments considering biosafety levels 1 to 3 (BSL 1 3)

Design projects (Concept Design, Basic Design, Detail Design, Procurement and Expediting):

Microbial fermentation for the production of small molecules (APIs, vitamines)
Cell culture-based production of biopharmaceuticals
Small organisms for the production of enzymes
CarT cells and stem cells
Vaccines

The design projects also include side facilities such as:

CIP Cleaning in place
SIP Sanitizing in place
Buffer and media preparations
Buffer storage and distribution
Cell banking
Waste water decontamination, chemical

Upstream processing (USP) and downstream processing (DSP) plants were designed either traditionally in stainless steel or for implementing Single Use Technology (SUT) including the impact of SUT on warehousing and building and site logistics.

With our experiences staff and biotech SMEs we have successfully completed more than 50 projects worldwide, which also includes the EBOLA facility project for Janssen Vaccines in Berne, Switzerland that was honored with the ISPE FOYA 2016 award.

Biotechnological production

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