Ambitious schedules, demanding processes and overlapping construction phases characterize the realization process of industrial plants in a GxP-regulated environment. However, with careful planning and preparation of the assembly phases, nothing stands in the way of the successful completion of a construction project. With experienced construction managers, Chemgineering coordinates the construction and assembly work of the various trades and checks whether the defined service has been provided and the quality of the work results is right.
The primary aim of time-saving parallel work is to create the framework conditions for a smooth and safe process on the construction site. Construction management has the task of coordinating the construction and assembly activities with a group of specialists and eliminating any difficulties that arise as quickly as possible in order to avoid undesirable effects on costs and deadlines. Only a team experienced and successful in construction management can meet these high requirements in terms of vigilance, problem-solving skills and discipline.
Benefit from "Constructability" experience at an early stage
With the construction manager's trained eye for "constructability", relevant aspects can already be incorporated into the tender for the assembly trades. The design of the construction site logistics and the sequence of operations provides important information on the delivery and transportation of the equipment to be procured and the work to be carried out at an early stage.
A construction manager involved in the planning of the investment project can advise the project manager and the process engineers on possible execution problems.
The earlier the construction manager can exert influence on execution details and construction strategy, the more reliably the project controlling specifications can be adhered to. His many years of construction site experience pay off, for example, when it comes to problems with bringing in bulky and heavy equipment, conflict zones between trades and constructability solutions (optimal construction).
Construction site safety
Building owners are responsible for safety on a construction site. A person must be designated on every construction site who is responsible for occupational health and safety. With well-trained health and safety coordinators, we ensure safe processes on your construction site.
Construction site logistics
Flow of goods, flow of people, special transports. Construction sites are complex areas, and the construction of industrial plants in GxP-regulated areas is a complex project. With forward-looking construction site logistics, we bring structure to the complexity and ensure the energy supply to the construction site, access to office, crew and material containers, the traffic concept and the transport routes.
Assembly monitoring
Deadlines are very tight due to the demanding logistics and the limited space available in existing plant areas. Chemgineering coordinates the entire execution and monitors compliance with the planning, specifications and applicable regulations. All processes are specified in detail and scheduled. Once the objects are in the right place, we check the installation quality, ensure acceptance by the customer and coordinate and monitor the rectification of defects. After quality assurance, the work is finally documented and handed over as-built, either object by object, package by package or as a whole.
How we make your GMP project a success
Comprehensive construction management involving all project managers
Early involvement of construction management in the construction project
Experienced site managers / construction management
Construction site safety - We take care of safety and health coordination for you
Construction site logistics - We manage the logistics of your construction site so that everything and everyone is in the right place at the right time
Installation supervision - Consistent monitoring of installation and quality assurance for optimum results
Relevant Projects
Building 305 - VAS10 - Centrifuge Plant & GMP Upgrade
House of Nutrition
New Facility HD15
Packaging System
60m³ Fermentation System
New Solids Launch Facility (NSLF)
Filling line for pre-filled syringes
New glycoenzyme production
F/3000 DSP Cystine León
Recombinant Ebola Vaccine Production
Hyaluronic Acid Filler Extension: New WFI System
Production Expansion for HA Filler
Eurofragrance
Eurofragrance
Eurofragrance
Eurofragrance
Designs of Labs, Research Center and Offices
Exhaust gas incinerator / RTO
Multi-purpose plant for fine chemicals production
COMAR Chemie AG, Expansion Stage 1
Pharmachem
Building 50 MZ 170
New PW generator & automation
New Office Building for Roche Diagnostics
Building 305 - VAS10 - Centrifuge Plant & GMP Upgrade
Centrifuge plant. Upgrade of a cone Dryer, GMP cabin for big bag filling
Customer
DSM Nutritional Products Ltd.
Location
Sisseln, Switzerland
Budget
7 Mio. CHF
Year
2 Years
Mandate
General Planner
Services
Support of Basic Design
Detail Design
CAD 3D (PDS)
Coordination of disciplines
Construction Management
Commissioning Support
House of Nutrition
Green field production of chemicals: Process euipment, process and building services, utilities and clean rooms.
Customer
Chemische Fabrik Budenheim
Location
Budenheim, Germany
Budget
25 Mio Eur
Year
4 Months
Mandate
Planning
Services
Project management
Conceptual design check
Basic Design
Cost estimation +/- 20%
Intelligent PIDs (Plant 3D)
BIM Model and Rendering
New Facility HD15
Planning and execution of a new plant (4 floors) for the production of natural products under high pressure conditions (supercritical CO2 up to 1,000 bar).
Customer
Hopfenveredelung St. Johann GmbH
Location
Wolznach, Germany
Budget
6 Mio. EUR (excl. Engineering Fees)
Year
3 Years
Mandate
General Planner
Services
Basic & detail engineering, support of the procurement process (tendering procedure, contract negotiations), construction management, support of commissioning
Chemical engineering departments: project management, HVAC incl. automation, process planning (building services, packaging unit, piping, 3-D model)
Special features: Process automation of the customer, relocation of existing process equipment (e.g. extraction system)
Packaging System
Planning, procurement and installation of a new packaging system. The packaging system is used for secondary packaging with shipping carton labeling of filled and checked sachets.
Customer
Nutrichem
Location
Roth, Germany
Budget
300.000 EUR
Year
1 Year
Mandate
Planning
Services
Conversion of the existing system
Basic and detailed design of the packaging system
Supplier selection and management
FAT implementation
Expediting
IBN support
60m³ Fermentation System
Conceptual design for the implementation of an upstream and downstream process in an existing building. The project included a 90m² clean room, 270 m² fermentation area (60 ³ capacity), a tank farm and utilities.
Customer
Phyton Biotech
Location
Ahrensburg, Germany
Budget
30 Mio. EUR
Year
4 Months (Planning), 2 Years (Implementation)
Mandate
General Planner
Services
Project coordination and scheduling
Process: Mass and energy balance, blow flow diagram, process flow diagram, concept for waste water treatment
Layout planning / 3D modelling: Personnel and material flow, conceptual planning of utilities, HVAC and building
Supplier coordination for key equiment
Cost estimates
Automation concept
New Solids Launch Facility (NSLF)
New building for the production and packaging of solid dosage forms and inhalation products.
Customer
Novartis Pharma AG
Location
Stein, Switzerland
Budget
500+ Mio. CHF
Year
5 Years
Mandate
General Planner Process
Services
Project management
Concept study, basic and detailed design
3D planning pure media supply
Construction management
Qualification
Procurement support
Expediting
Document management
Filling line for pre-filled syringes
Planning of a filling line for pre-filled syringes in Switzerland, including planning of all process systems and building infrastructure through to commissioning.
Customer
International Pharmaceutical Manufacturer
Location
Switzerland
Budget
35 Mio. CHF
Year
3 Years
Mandate
General Planner
Services
Project management
Planning for all process systems and entire building infrastructure in existing production building (ventilation, clean room, connection to energy and media supply, incl. EMSR and building automation)
Conceptual design, basic design, detail design
Procurement support, expediting
Support for installation management (conversion during ongoing operations)
Planning of a production plant for endoglycosiadases (and in future also mRNA). Microbiological plant (yeasts and bacteria) with 30l / 300l (after expansion) fermentation volume. Planning as a classic upstream-downstream plant with single-use technology for fermentation and purification.
Customer
Daiichi-Sankyo
Location
Pfaffenhofen, Germany
Budget
Confidential
Mandate
General Planner & General Contractor
Services
Concept design, basic design, detail design
All trades
Investment cost estimation, value analysis
URSs
Preparation of schedules
F/3000 DSP Cystine León
Downstream process for the production of cystine powder.
Customer
Wacker
Location
León, Spain
Budget
10 Mio. EUR
Year
2 Years
Mandate
Engineering, Procurement and Construction Management (EPCM)
Services
Basic and detail engineering
3D planning
Purchasing
Construction management
Support during commissioning
Recombinant Ebola Vaccine Production
Conversion of a production facility, USP and DSP, for cell culture-based vaccine production, including adaptation of media, clean rooms, HVAC and chemical wastewater inactivation.
Customer
Janssen Vaccines AG (J&J, ex. Crucell)
Location
Bern, Switzerland
Budget
8. Mio EUR
Year
2 Years
Mandate
General Planner
Services
Concept design, process layout, basic design, incl. HSE and GMP reviews, detail design
Disposable equipment installation
Conversion of ventilation & media supply
Construction management and commissioning
Planning and implementation of chemical wastewater inactivation
Hyaluronic Acid Filler Extension: New WFI System
Thermo (Vapor) Compression WFI-Erzeuger-, Lager- und Verteilsystem für WFI, Reindampf.
Planning, execution and commissioning of GMP production rooms and laboratories including process media.
Customer
Merz Anteis SA
Location
Lonay, Switzerland
Budget
Confidential
Year
1 Year
Mandate
General Planner
Services
Development of layout variants
Planning, tendering and construction site management:
TGA
Cleanrooms
Cleanroom and airlock furniture
Electrical and sanitary installations
Process media and distribution (gases, vacuum and WFI)
Construction activities
WFI production and storage
2 GMP washing machines
Qualification support
Eurofragrance
New construction of offices and laboratories for research and development.
Customer
Eurofragance
Location
Dubai, United Arab Emirates
Budget
Confidential
Year
2 Years
Mandate
Confidential
Services
Concept Design
Basic Design
Detail Design
Procurement
Construction Management
Eurofragrance
New offices and laboratories for research and development.
Customer
Eurofragance
Location
Singapore
Budget
Confidential
Year
2 Years
Mandate
Confidential
Services
Concept Design
Basic Design
Detail Design
Procurement
Construction Management
Eurofragrance
New research and development laboratories and new offices.
Customer
Eurofragance
Location
Sant Cugat del Vallès, Barcelona, Spain
Budget
Confidential
Year
1 Year
Mandate
Confidential
Services
Detail project
Procurement and Construction Management
Eurofragrance
Two-storey refurbishment in an office building. Updated and customized design for offices, showrooms, laboratories, meeting rooms and services.
Customer
Eurofragance
Location
Vallsolana site - Kibo Building, Sant Cugat del Vallès, Barcelona, Spain
Budget
Confidential
Year
2 Years
Mandate
Confidential
Services
Pre-study
Basic evaluation
Detail planning
Construction management
Designs of Labs, Research Center and Offices
New production plant, research center and offices. Extended warehouse in reception, dispatch and picking areas.
Customer
Laboratorios Dermofarm
Location
Rubí, Barcelona, Spain
Budget
Confidential
Year
9 Years
Mandate
Confidential
Services
Preliminary study, basic project, detailed project, procurement and construction management for the new plant
Preliminary study for the expanded production areas
Basic project, detailed project, procurement and construction management for the expanded incoming goods, shipping and order picking areas
Exhaust gas incinerator / RTO
Disposal of solvent-containing exhaust air, 12`000 Nm3/h Regenerat. therm. Oxidation (RTO): Process and source exhaust air, exhaust air from waste water treatment plant and industrial waste water systems.
Customer
Industriepark Baselland (Clariant)
Location
Muttenz, Switzerland
Budget
4 Mio. CHF
Year
3 Years
Mandate
General Planner
Services
Concept study with comparison of variants
Basic and detailed planning
Procurement, overall construction management, commissioning
Risk analyses
Estimation of investment and operating costs
Multi-purpose plant for fine chemicals production
Fine chemicals multi-purpose plant with stirred tank, centrifuge, dryer, rectification, (corrosion-resistant).
Customer
CABB AG
Location
Pratteln, Switzerland
Budget
32 Mio. CHF
Year
2 Years
Mandate
General Planner
Services
Project management
Concept planning incl. cost estimation
Basic design: process engineering, infrastructure, construction incl. statics, instrumentation
Production plant for the manufacture of neodymium catalysts.
Customer
COMAR Chemie AG
Location
Muttenz, Switzerland
Budget
4.5 Mio. CHF
Year
1 Year
Mandate
General Planner
Services
Concept and basic engineering
Detail engineering (CAD-3D)
Submissions to authorities
HAZOP
Construction and assembly management
Technical purchasing / procurement
Schedule and cost control
Supplier and as-built documentation
Pharmachem
Construction of a production building for APIs and intermediates; 100 m3 reaction capacity, batch process.
Customer
PharmaChem Technologies
Location
Freeport, Bahamas
Budget
Confidential
Year
3 Years
Mandate
General Planner
Services
Basic Design
Detail Design
Support with construction management (Structural and civil engineering, process and operating technology)
Building 50 MZ 170
Multi-purpose plant for the production of final & finishing steps for active pharmaceutical ingredients 3 HC-22 reactors of 6.3 m3 each, HC-22 centrifuge, infrastructure.
Customer
F. Hoffmann-La Roche AG
Location
Basel, Switzerland
Budget
30 Mio. CHF
Year
2 Years
Mandate
Detail Planning
Services
Support for VT engineering
Basic and detail engineering
CAD 3D planning (PDS)
Coordination of the construction/containment, steel construction and HVAC trades in the 3D model
Support for assembly and commissioning
New PW generator & automation
Procurement of new PW generators, adaptation of automation incl. connection to BMS + MAS, dismantling of existing generators.
Customer
Novartis Pharma AG
Location
Wehr, Germany
Budget
500.000 EUR
Year
1 Year
Mandate
General Planner
Services
Concept planning
Basic and detail engineering
Preparation of URS and tender documents
Installation and commissioning support
GxP, functional and HSE risk analyses
Qualification plans
Coordination and implementation of qualification activities (DQ, IQ, OQ)
New Office Building for Roche Diagnostics
Planning, procurement and construction management of the new Roche Diagnostics office building in Spain. Offices, training rooms, demonstration rooms, dining room and auditorium were planned by Chemgineering and implemented in detail, including architecturally, and managed during construction.
Customer
Roche Diagnostics
Location
Sant Cugat del Vallès (Barcelona), Spain
Budget
Confidential
Year
4
Mandate
Confidential
Services
Basic Project
Detailed project for architectural work and facilities
Procurement and construction management
If you have any questions about construction management, please contact us
We help you to successfully implement your project.
With professional construction management in GMP-regulated areas. Get in touch with us.